Dr Ferran Nadeu speaks to ecancer about minor independent clones in patients with chronic lymphocytic leukaemia have a CLL-biased biological signature: Implications for disease ontogeny and evolution.

The study explores the origins and evolution of chronic lymphocytic leukaemia (CLL) by analysing over 350 patients with multiple independent clones. Researchers find that about 12% of patients show an oligoclonal pattern, indicating multiple CLL clones.

Advanced technologies reveal that these clones have unique mutations and that early CLL phases exhibit higher oligoclonality, providing insights for potential early detection and intervention strategies.