Blood tumour mutational burden and response to pembrolizumab plus chemotherapy in non-small cell lung cancer

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Published: 29 Apr 2024
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Prof Jair Bar - Sheba Medical Center, Tel-Aviv, Israel

Professor Jair Bar speaks to ecancer about the KEYNOTE-782 trial.

This trial aimed to determine the correlation between blood tumour mutational burden (bTMB) and the efficacy of first-line pembrolizumab plus chemotherapy in patients with non-small cell lung cancer (NSCLC).

The study's results showed that the adverse events observed were consistent with the known safety profile of first-line pembrolizumab plus chemotherapy in NSCLC.

However, the baseline bTMB did not show any evidence of being associated with efficacy.