Concurrent low-dose radiation and durvalumab and etoposide/platinum shows promising efficacy in 1L ES-SCLC

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Published: 6 Apr 2024
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Dr Yan Zhang - Sichuan University, Chengdu, China

Dr Yan Zhang speaks to ecancer about a phase II study of low-dose radiation (LDRT) plus durvalumab and etoposide/platinum as first-line treatment in ES-SCLC.

This study presented the efficacy and safety results from the LEAD study. The primary endpoint of this trial was progression-free survival and the secondary endpoints included overall survival and safety.

The results showed that concurrent low-dose radiation and durvalumab and etoposide/platinum present promising prolonged mPFS in 1st line ES-SCLC and were well-tolerated.