Researchers at the University of California San Diego Centre for Epigenomics (C4E) have developed a new technique, called Droplet Hi-C, that allows scientists to rapidly determine chromatin organisation, the arrangement of genetic material within cells.

Chromatin organisation influences how genes are activated in our cells and, in turn, how those cells function.

In addition to being faster than existing methods for studying chromatin organisation, droplet Hi-C is more affordable, which could make it significantly easier for scientists to understand how genes influence the progression of complex diseases, such as cancer and neurological disorders.

The researchers have already deployed the technique, which works by capturing individual cells in tiny droplets, to study chromatin organisation in mouse brain cells and in human tumours.

In the long term, Droplet Hi-C could drive the discovery of new drug targets and help explain how cancer evolves to resist treatment.

The technique may also have applications in clinical settings, where it could provide personalised insights into disease progression and treatment options.

The study, published October 18 in Nature Biotechnology, was led by Bing Ren, Ph.D., director of the C4E and a professor in the Department of Cellular & Molecular Medicine at UC San Diego School of Medicine.

Source: University of California - San Diego