Scientists at City of Hope, one of the largest cancer research and treatment organisations in the United States, have identified how low levels of the TET2 gene fuel the rapid growth of acute myeloid leukaemia in animal models.
Cell Stem Cell recently published the study.
A team led by Jianjun Chen, Ph.D., the Simms/Mann Family Foundation Chair in Systems Biology at Beckman Research Institute of City of Hope, found that TET2 deficiency sets off a cascade of biochemical changes that enhance the bone marrow cancer’s ability to spread.
These changes include:
By expanding understanding of the multiple ways that TET2 influences the development of acute myeloid leukaemia, the discovery points to new potential therapeutic targets for treating the disease.
“This study provides novel insights into the cellular and molecular mechanisms underlying the development of acute myeloid leukaemia,” Chen said.
“Our findings highlight the therapeutic potential of reactivating TET2 signalling in patients with TET2 mutations or transcriptional suppression. Equally exciting, this strategy could be applied to other types of cancer that feature TET2 deficiency.”
Acute myeloid leukaemia is distinguished by the rapid division and spread of immature leukaemia stem cells.
More than half of patients relapse, and the five-year survival rate is only 30%.
Figuring out how to destroy these cells is crucial to effectively treat the disease.
TET2 deficiency cooperates with leukaemia-related oncoproteins resulting from chromosomal abnormalities or gene mutations to drive the development of leukaemia and enhance malignant stem cells’ ability to divide and spread.
Until now, however, the cellular and molecular mechanisms underlying these processes have remained murky.
In analysing data from the Cancer Genome Atlas, Chen and his colleagues found that lower expression or mutation of TET2 was associated with a poor prognosis and shorter overall survival rates for patients.
Compared to healthy control subjects, TET2 expression was significantly suppressed in acute myeloid leukaemia patients.
This led the team to investigate the clinical relevance of TET2 in the development of the disease.
Source: City of Hope
The World Cancer Declaration recognises that to make major reductions in premature deaths, innovative education and training opportunities for healthcare workers in all disciplines of cancer control need to improve significantly.
ecancer plays a critical part in improving access to education for medical professionals.
Every day we help doctors, nurses, patients and their advocates to further their knowledge and improve the quality of care. Please make a donation to support our ongoing work.
Thank you for your support.