ecancermedicalscience

Short Communication

Learning from the past to design better trials in second-line treatment for mesothelioma patients

8 Nov 2018
Alfredo Addeo, Giuseppe Luigi Banna, Pierre-Yves Dietrich

Malignant pleural mesothelioma (MPM) is an aggressive cancer characterised by modest sensitivity to systemic chemotherapy. The standard treatment remains platinum-based chemotherapy with pemetrexed. Recently, the addition of an antiangiogenic drug, bevacizumab, to first-line chemotherapy has been shown to improve overall survival. All the patients, unfortunately, will progress, and currently, there is no standard treatment approved in second-line. Recently, the results of the NGR015 phase III randomised with NGR-hTNF plus chemotherapy versus placebo in addition to physician’s choice second-line chemotherapy for MPM have been published. Despite encouraging data achieved in previous phase I and phase II studies, the NGR-hTNF drug failed to meet the primary endpoint of the study, although a signal of activity was observed in the group of patients who had a shorter treatment failure interval from the first-line treatment.

Hereby, we start from this recent trial to highlight once more the importance of thoroughly investigating possible predictive factors during the early drug development phase to allow more efficient phase III trial design, thus avoiding the possibility of potentially effective molecules like NGR-hTNF, continuing to be wasted.

Article metrics: 353 views
206
147

Related Articles

Luis Larrea, Enrique López, Paola Antonini, Verónica González, Miguel Ángel Berenguer, Maria Carmen Baños, Jose Bea, Jose Domingo
Akhil Kapoor, Vanita Noronha, Vijay M Patil, Amit Joshi, Nandini Menon, Abhishek Mahajan, Amit Janu, Kumar Prabhash
Muhammad Shahid Iqbal, Joseph Carlow, Fiona McDonald, Philip Atherton, Helen Turnbull, Sandeep Singhal, Timothy Simmons, Paula Mulvenna, Josef Kovarik, Rhona McMenemin, Jill Gardiner, Alastair Greystoke
Viviane Teixeira Loiola de Alencar, Maria Nirvana Formiga, Vladmir Cláudio Cordeiro de Lima
Guilherme Harada, Fernando Costa Santini, Felipe Sales Nogueira Amorim Canedo, Leandro Jonata de Carvalho Oliveira, Henrique Bortot Zuppani, Gilberto de Castro Jr