ecancermedicalscience

Case Report

Fatal interstitial lung disease caused by Panitumumab-containing chemotherapy regimen

7 Jun 2018
Osamah Al-asadi, Manar Almusarhed, Syed Azhar J Rizvi, Wasiru Saka

Fatal interstitial lung disease (ILD) is one of the rare side effects of Panitumumab. Both fatal and non-fatal ILD have been reported mainly in the Japanese population. We report a case of a nonsmoking Caucasian man with the diagnosis of metastatic rectal cancer (K-RAS wild-type) who developed fatal ILD after receiving a Panitumumab-containing chemotherapy regimen. He initially presented with a locally advanced rectal cancer (T3N2M0) for which he received neoadjuvant chemoradiotherapy. Before the rectal surgery, he was found to have liver metastases which were considered potentially resectable. The decision was to delay the rectal surgery and to start systemic treatment. He was started on Modified De Gramont regimen (folinic acid and fluorouracil) plus Oxaliplatin with Panitumumab. Six months later, he underwent rectal surgery which showed a complete response. He continued on systemic treatment while awaiting liver metastasectomy. After three courses of Modified De Gramont plus Oxaliplatin with Panitumumab, he was admitted with few days’ history of increasing shortness of breath. High-resolution computed tomography of the lungs showed the features of interstitial pneumonitis. Despite receiving appropriate treatment, he continued to deteriorate and died due to respiratory failure.

Article metrics: 1747 views
304
1443

Related Articles

Luis Larrea, Enrique López, Paola Antonini, Verónica González, Miguel Ángel Berenguer, Maria Carmen Baños, Jose Bea, Jose Domingo
Rachel P Riechelmann, Renata D’Alpino Peixoto, Gustavo Dos Santos Fernandes, Rui F Weschenfelder, Gabriel Prolla, Duilio Rocha Filho, Aline Chaves Andrade, Marcela Crosara, Juliana Florinda M Rego, Rene C Gansl, Felipe Coimbra, Samuel Aguiar Jr, Elisângela Carvalho, Paulo M Hoff, Anelisa K Coutinho
Charlien Berghen, Steven Joniau, Christof Vulsteke, Maarten Albersen, Gaëtan Devos, Kato Rans, Karin Haustermans, Gert De Meerleer
Chakra P Chaulagain, Adalberto Gonzalez, Isaac Goldszer, Luis Caraballo, James E Hoffman, Leah Elson, Maria-Julia Diacovo
Nieves Martínez Lago, María Vieito Villar, Rafael Varela Ponte, Ihab Abdulkader Nallib, Juan José Carrera Alvarez, José Ramón Antúnez López, Rafael López López, María Elena Padin Iruegas