ecancermedicalscience

Clinical Study

Ovarian cancer in BRCA1 and BRCA2 gene mutation carriers: analysis of prognostic factors and survival

3 May 2016
Nicoletta Biglia, Paola Sgandurra, Valentina Elisabetta Bounous, Furio Maggiorotto, Eleonora Piva, Emanuele Pivetta, Riccardo Ponzone, Barbara Pasini

Objectives: To compare clinical–pathological characteristics and outcome between sporadic ovarian cancer and ovarian cancer in patents with hereditary breast and ovarian cancer syndrome (HBOC).

Methods: Twenty-four patients with ovarian cancer treated between 2000 and 2009 who tested positive for BRCA1/2 mutation (BRCA) and a control group of 64 age-matched patients with no family history of breast/ovarian cancer (controls) were enrolled. Clinical–pathological characteristics, surgical outcome, overall (OS), and progression-free survival (PFS) were compared between the two groups.

Results: The high-grade serous histotype was more represented in BRCA than in controls (70.8% versus 53.1%) (p > 0.05). BRCA cancers were more frequently diagnosed at stage II than controls (20.83% versus 4.69%) (p = 0.024). Radical primary surgery was performed in 70% of women in both groups, with no difference in debulking results. In patients undergoing surgery after neoadjuvant chemotherapy, in all BRCA patients, optimal cytoreduction was achieved (versus 70% of the controls). PFS was significantly longer for BRCA patients compared to controls (60 months versus 22 months; p = 0.039). No significant difference was observed in OS between BRCA patients and controls.

Conclusions: At a median follow-up time of 46 months, BRCA patients have a better prognosis than controls in terms of PFS. Higher chemosensitivity of BRCA tumours was observed.

Related Articles

Milagros Abad-Licham, Christian Cotrina, Andric Guerrero, Katherine Gómez, Juan Astigueta
Eva Maria Ruiz de Castilla, Maurice Mayrides, Haydée González, Francisco Vidangossy, Tatiana Corbeaux, Nancy Ortiz, Claudia Amaya, Alexandra Nuñez, Diego Fernando Jimbo Jimbo, Adela Ayensa, Mayra Galindo, Karla Ruiz, Juan Manuel Pérez
Olaniyi A Olatunde, Modupeola O Samaila, Mohammed I Imam, Kasiemobi E Uchime, Suleiman E Dauda
Kofi Effah, Ethel Tekpor, Comfort Mawusi Wormenor, Nana Owusu Mensah Essel, Seyram Kemawor, Edna Sesenu, Stephen Danyo, Yohane Teye Kitcher, Gifty Belinda Klutsey, Georgina Tay, Faustina Tibu, Kofi Antwi Abankroh, Bernard Hayford Atuguba, Patrick Kafui Akakpo