ecancermedicalscience

Case Report

Follicular thyroid carcinoma in a patient with myasthenia gravis and thymoma: a rare association

18 Oct 2012
H Ni, A Htet

Myasthenia gravis (MG) is an autoantibody-mediated disorder affecting the neuromuscular junction causing characteristic fatigable muscle weakness. Though it can be associated with tumours of the thymus as well as thyroid disorders, it is rare for both to coexist. The exact prevalence of thyroid carcinoma in MG with thymoma is not known but only about a dozen cases have been reported in the literature. We report a case of a 38-year-old Myanmar lady who presented with weakness and breathlessness due to MG with neck swelling. On examination, she had fatigable proximal muscle weakness and thyroid enlargement with no obvious features of hyperthyroidism. Mediastinal widening and an enlarged thyroid gland were noted on her chest X-ray and chest CT. A subtotal thyroidectomy and thymectomy were done. The histology showed follicular carcinoma of the thyroid and benign thymoma. The majority of the reported cases of thyroid carcinoma in association with MG were papillary carcinoma. Follicular carcinoma thyroid associated with MG has not yet been reported in
the literature.


Keywords: myasthenia gravis, thymoma, follicular carcinoma of thyroid, thyroid carcinoma

Related Articles

Suzanne T Nethan, Dhirendra N Sinha, Ashwini Kedar, Vipin Kumar, Shashi Sharma, Roopa Hariprasad, Ravi Mehrotra
Ntokozo Ndlovu, Sandra Ndarukwa, Albert Nyamhunga, Patience Musiwa-Mba, Anna Mary Nyakabau, Webster Kadzatsa, Melinda Mushonga
Patricio Salas, Maria Eliana Solovera, Felipe Bannura, Matias Muñoz-Medel, Miguel Cordova-Delgado, Cesar Sánchez, Carolina Ibáñez, Marcelo Garrido, Érica Koch, Francisco Acevedo, Sebastián Mondaca, Bruno Nervi, Jorge Madrid, José Peña, Mauricio P Pinto, José Valbuena, Héctor Galindo
Saira Saleem, Iffat Aleem, Aribah Atiq, Sahrish Tariq, Amna Babar, Muhammad Abu Bakar, Madiha Syed, Maheen Maruf, Mohammad Tariq Mahmood, Muhammad Zeshan, Muhammad Tahseen, Raza Hussain, Asif Loya, Chris Sutton