ecancermedicalscience

Case Report

Histological subtype of gastric adenocarcinoma: two cases of mixed fundic and pyloric mucosa-type adenocarcinoma

13 Nov 2020
Haruhiko Takahashi, Kenshi Yao, Tetsuya Ueo, Takashi Nagahama, Kentaro Imamura, Kenta Chuman, Hiroshi Tanabe, Akinori Iwashita, Toshiharu Ueki

Adenocarcinomas with differentiation towards fundic or pyloric glands are rare histological subtypes. We herein describe two cases of new histological subtypes: mixed fundic and pyloric mucosa-type adenocarcinoma detected in Helicobacter pylori uninfected patients. The first patient was a woman in her 40s. A glossy, reddish, nodular lesion with a flat elevated whitish area was detected at the gastric fundus. When the nodular lesion was visualised with magnifying narrow-band imaging (M-NBI), an absent microvascular pattern plus an irregular microsurface pattern with a demarcation line was observed. The second patient was a woman in her 60s. A glossy, reddish, elevated lesion was detected at the gastric body. M-NBI finding was a regular microvascular pattern plus a regular microsurface pattern with a demarcation line. Histological examination of the resected specimens from both cases showed a very well- to well-differentiated adenocarcinoma which has differentiation towards the mixed fundic and pyloric mucosa. The histological and serological findings of both cases indicated the absence of H. pylori infection. The present two cases demonstrate further evidence of a new histological subtype of gastric adenocarcinoma: mixed fundic and pyloric mucosa-type adenocarcinoma, which has distinct characteristic endoscopic findings.

Article metrics: 125 views
108
17

Related Articles

Luis Villanueva, Jaime Anabalón, Jean M Butte, Pamela Salman, Sergio Panay, Elizabeth Milla, Carlos Gallardo, Sebastian Hoefler, Roberto Charles, Felipe Reyes, Olga Barajas, Luis Matamala, Angelica Molina, Sergio Portiño, Marcela Berrios, Christian Caglevic, Mauricio Mahave
Luca Nicosia, Antuono Latronico, Mariagiorgia Farina, Anna Carla Bozzini, Paola Baratella, Viviana Enrica Galimberti, Stefano Fiori, Marta Montesano, Enrico Cassano
Maria Asunción Algarra, Maria José Juan Fita, Sergio Sandiego, Héctor Augusto Aguilar, Pablo Álvarez, Mateo Quispe, Antonio Salvador, Adoración Egido, Javier Lavernia, Isidro Machado, José Rubio Briones, Miguel Ángel Climent
Milagros Abad-Licham, Juan Astigueta, Caddie Laberiano Fernández, Himelda Chávez Torres, Grisnery Maquera Torres, Edwin Figueroa, Ricardo Bardales
Elham Sajjadi, Konstantinos Venetis, Cristian Scatena, Nicola Fusco
Lotfi Kochbati, Verna Vanderpuye, Rim Moujahed, Mouna Ben Rejeb, Zeineb Naimi, Tajudeen Olasinde