NCI/CCR and SITC will co-sponsor a 2016 Biomarkers meeting to review the state of the art, discuss current hurdles to further success, and consider recommendations to move the field forward. The main goals are to provide updated information to a wide audience and solicit stakeholder participation in promoting successful immune biomarker research. This one-day event will be divided into four didactic sessions representing the four working groups of the SITC 2015-2016 Immune Biomarkers Task Force. Each session will include presentations by members of one working group followed by a 30-minute panel discussion designed to engage workshop participants in productive conversation and debate.