This first ever Fusion Conference focused on the biology and therapy of Myeloid malignancies aims to bring together leading experts to discuss the latest advancements and current challenges in this rapidly evolving field. This conference will provide a comprehensive overview of basic, translational, and clinical research, highlighting the collaborative efforts to improve our understanding and treatment of myeloid malignancies. This is a fast-evolving area, where significant strides have been made in uncovering the molecular and genetic foundations of the large variety of myeloid neoplasms and also pre-neoplastic conditions. Also, it is an area that has been marked by a number of technologic advances, including in computational analysis, single cell sequencing and spatial omics mapping in different tissues and microenvironments. The meeting will also highlight efforts to translate basic research findings into clinical applications.