One of our most popular conferences, Defence is the Best Attack 2023 will be our fourth on this topic. Participants will learn about the most recent advances in immunotherapy, from the  basic science to clinical studies, including the identification of novel targets. Topics to be covered immune checkpoints and innate immune response, microbioma, immune cell therapies, vaccines, and biomarkers of response to and mechanisms of resistance to immunotherapy. Alberto Montovani (Humanitas University), Tyler Jacks (MIT, USA), and Josep Tabnernero (VHIO, Spain) will give keynote speeches.