The interplay between cell death, cell stress and metabolism plays a crucial role in shaping normal turnover of tissues, in sensing of danger posed by pathogens or other damage and the immunological response that is mounted to response to them. At this conference we will discuss the basic biological principles that govern cell death, cell stress and metabolism. We will also cover how cellular stress and alterations in metabolism influence the cellular death programs such as apoptosis, necroptosis, ferroptosis and others.  Importantly, this conference aims to become the go-to forum at which the most current and up-to-date therapeutic avenues in the fields of cell death, cell stress and metabolism will be presented and discussed.