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ASH 2015 /
How do genes influence the development of chronic idiopathic thrombocytopenic purpura?

5th - 7th Dec 2015

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Published: 07.12.15
Views: 1944

Prof Jenny Despotovic - Texas Children's Cancer Center, Houston, USA

Prof Despotovic talks to ecancertv at ASH 2015 about the results of a study that looked for genes that may be involved in the development of chronic immune thrombocytopenia (ITP) in children using whole exome sequencing.

Historically, chronic ITP has not been thought of as a genetic or inherited disease, Dr Despotovic says. The results of the study she presented at ASH 2015 showed that genetic anomalies can be found in children with the disorder. These anomalies include changes in the gene encoding interferon-alpha 17, which is involved in the activation of regulatory T cells and TGF-β signalling.

The hope is that these findings will help researchers understand ITP biology better to enable the identification and stratification of patients and improve treatment by avoiding unnecessary toxicity.

Read the news story and watch the press conference presentation for more information.

Previous conferences: highlights



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation