Long-term follow-up of low-intensity chemotherapy with combination therapy for r/r Ph- acute lymphoblastic leukaemia patients

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Published: 22 Dec 2020
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Prof Hagop Kantarjian - MD Anderson Cancer Center, Houston, USA

Prof Kantarjian speaks to ecancer about a study presented at ASH 2020 regarding a phase 2 trial; long-term follow-up of the combination of low-intensity chemotherapy plus inotuzumab ozogamicin with or without blinatumomab in patients with relapsed-refractory Philadelphia chromosome-negative acute lymphoblastic leukaemia.

He says that the outcome of patients with relapsed-refractory (R/R) acute lymphoblastic leukaemia (ALL) is poor.

Inotuzumab ozogamicin and blinatumomab are highly active single agents in R/R ALL. The combination of inotuzumab with low-intensity mini-hyper-CVD chemotherapy showed encouraging results in this patient population.

The sequential addition of blinatumomab optimises the efficacy of the regimen, reduce its toxicities, and further improve outcomes in R/R ALL.

He says that the aim of the analysis was to evaluate the efficacy and safety of inotuzumab ozogamicin plus low-intensity chemotherapy with or without blinatumomab in R/R ALL.

Prof Kantarjian then explains the key results from this study and how they can impact the future treatment of Ph- ALL.

ecancer's filming has been kindly supported by Amgen through the ecancer Global Foundation. ecancer is editorially independent and there is no influence over content.