Regulating haematopoietic stem cell dormancy and ageing through the netrin-1-neogenin axis

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Published: 13 Jun 2020
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Dr Simon Renders - German Cancer Research Center (DKFZ), Heidelberg, Germany

Dr Simon Renders speaks to ecancer about the study he presented during the presidential symposium at the EHA 2020 virtual meeting.

He summarises the background of the study, which identified netrin-1 as a regulator of haematopoietic stem cell dormancy and function through its receptor, neogenin.

Dr Renders also explains the implications this pathway could have for stem cell ageing, along with the methods used for this study.