Prof Suresh Ramalingam speaks to ecancer about results from the three-year update from the CheckMate 227 study into nivolumab plus ipilimumab versus platinum-doublet chemotherapy as first-line treatment for advanced non-small cell lung cancer (NSCLC) presented at the 2020 ASCO Virtual Meeting.
He reports that the three year survival rate for patients with PD-L1 expression greater than 1% and treated with nivolumab plus ipilimumab was 33% compared to 22% for the chemotherapy group.
Prof Ramalingam also reports that in the PD-L1 expression less than 1% group the three year survival rate with nivolumab plus ipilimumab was 34% compared to 15% for the chemotherapy group.
He also highlights that the durability of the responses was around 3 to 4 times longer in the nivolumab plus ipilimumab groups compared to the chemotherapy groups.
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