TROPHY-U-01: Sacituzumab govitecan in patients with mUC after failure of platinum-based regimens or immunotherapy

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Published: 7 Oct 2019
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Dr Scott Tagawa - Weill Cornell Medicine, New York City, USA

Dr Scott Tagawa speaks to ecancer at ESMO 2019 in Barcelona about the phase II TROPHY-U-01 study evaluating the use of sacituzumab govitecan in patients with metastatic urothelial cancer (mUC) after failure of platinum-based regimens or immunotherapy.

He explains that the main cohort contained 100 evaluable patients with mUC and progression of disease despite both platinum-based chemotherapy and checkpoint inhibitors.

Dr Tagawa reports that the response rate overall was 29% which was a marked improvement over single agent chemotherapy.