Gene expression in primary non-small cell lung cancer as a predictor of brain metastases

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Published: 10 Jul 2019
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Dr Jair Bar - Sheba Medical Center, Tel Hashomer, Israel

Dr Jair Bar speaks to ecancer at the WIN 2019 Symposium in Paris about the use of gene expression in primary non-small cell lung cancer (NSCLC) to identify patients at risk of developing brain metastases.

He mentions how these lung cancer patients may be prone to developing brain metastases and how these underlying mechanisms are poorly understood.

By comparing resected tumours after surgery between patients with and without brain metastases, it was possible to identify a set of predictive genes for brain metastases rather than relying solely on clinical data.

In terms of underlying mechanisms, Dr Bar states that oxidative phosphorylation was found to be increased in patients with brain metastases.