CheckMate142: Checkpoint combination therapy in first-line colorectal cancer

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Published: 26 Oct 2018
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Dr Heinz-Josef J. Lenz - Keck School of Medicine of USC, Los Angeles, USA

Dr Lenz speaks with ecancer at ESMO 2018 in Munich about the CheckMate 142 trial of nivolumab with ipilimumab as first-line therapy in DNA mismatch repair deficient (dMMR) and microsatellite instability-high (MSI-high) metastatic colorectal cancer (mCRC).

He outlines previous research into differing doses of the combination, and reports the improved disease control rate, response rate and tolerability of this trials 6 week schedule.

The use of checkpoint combination therapy in early colon cancer as neo-adjuvant therapy is also discussed by Dr Myriam Chalabi.