IG rearrangement, JAK1/2 inhibition and aggressive B-cell lymphoma development...

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Published: 10 Jul 2018
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Prof Veronika Sexl - University of Veterinary Medicine of Vienna, Vienna, Austria

Dr Sexl speaks with ecancer at EHA 23 about findings implicating modulation of the JAK-STAT pathway in the transition of myelofibrosis to B cell lymphoma.

She describes the mixed signals of the disease transitioning from one to the other, and the existence of a hidden, amplified B cell clone which drives the aggressive lymphoma.

Dr Sexl recommends screening for this clonal population in patients eligible for JAK-STAT inhibition.