Dr Rosario Pivonello speaks about his work searching for new effective treatments for pituitary tumours and offers advise to doctors when diagnosing these rare diseases. Dr Pivonello explains how Cushing’s disease is currently treated and stresses the need for new medical therapies. Pasireotide is a promising new drug in development for Cushing’s disease; Dr Pivonello explains why pasireotide has the potential treat this Cushing’s more effectively than existing somatostatin analogues and discusses the difference it could make to clinical practice.