Tandem duplicator phenotypes define 50% of triple negative breast cancers

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Published: 7 Dec 2017
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Dr Ed Liu - The Jackson Laboratory, Bar Harbor, USA

Dr Ed Liu speaks with ecancer at SABCS 2017 about the tandem duplicator phenotype as a distinct genomic configuration in cancer.

He describes how next-generation sequencing studies have revealed genome-wide structural variation patterns in cancer, such as chromothripsis and chromoplexy, that do not engage a single discernable driver mutation, and whose clinical relevance is unclear.

Dr Liu devised a robust genomic metric able to identify cancers with a chromotype called tandem duplicator phenotype (TDP) characterised by frequent and distributed tandem duplications (TDs).

He concludes that TDP is a common cancer chromotype that coordinately alters oncogene/tumour suppressor expression with potential as a marker for chemotherapeutic response.