IKZF1 mutations associated with paediatric ALL

Bookmark and Share
Published: 5 Dec 2016
Views: 1772
Rating:
Save
Dr Michelle Churchman - St. Jude Children's Research Hospital, Memphis, USA

Dr Churchman speaks with ecancertv at ASH 2016 about the mutations in IKZF1, or Ikaros, that are associated with worse outcomes for childhood leukaemia.

She outlines a suite of heritable mutations which result in a stem-like behaviour, cell adhesion and drug resistance within the bone marrow.

Dr Churchman explains how next generation sequencing could help in identifying patients most suited to targeted therapy.

ecancer's filming at ASH 2016 has been kindly supported by Amgen through the ECMS Foundation. ecancer is editorially independent and there is no influence over content.