Daratumumab, bortezomib/thalidomide/dexamethasone (D-VTd) and DARA maintenance shows benefit in transplant-eligible NDMM
Prof Ulrich Jäger from Medical University of Vienna, Austria discusses the rituximab maintenance trial in patients with aggressive lymphoma (diffused large b-cell lymphoma mainly) who have achieved complete remission or unconfirmed complete remission. He notes how the trial has shown that the male low-risk population could profit from higher doses of rituximab or longer treatment periods.
Prof Jäger celebrates the different drugs available to patients with CLL. However, he concludes that this 'luxury problem' requires molecular data and a bio-informatic tool for the end doctor to chose the right trial and/or treatment for the patient as the patient populations become further targeted and so smaller, especially when considering the potential cost for long-term treatment programmes.
To conclude Prof Jäger comments that he would like to see further investigations in drug combinations and more coordination between trials, to allow for better comparisons.
Read our ASH 2013 conference report for free
Daratumumab, bortezomib/thalidomide/dexamethasone (D-VTd) and DARA maintenance shows benefit in transplant-eligible NDMM
Treating relapsed multiple myeloma outside of use of T-cell redirected therapies
Isatuximab, plus bortezomib, lenalidomide, and dexamethasone shows improved PFS in frail NDMM patients
Isa-KRd quad regimen in NDMM: MIDAS and CONCEPT studies
Isatuximab in combination with pomalidomide and dexamethasone shows promising efficacy in 2nd line RRMM
ASCO 2024: Two studies report on isatuximab combos in transplant-ineligible patients with newly diagnosed multiple myeloma
Multiple myeloma in a resource constrained setting
Significant clinical benefits observed with revumenib monotherapy in relapsed/refractory KMT2Ar acute leukaemia
Ide-cell enhances health-related quality of life for refractory multiple myeloma