How malignant cells in patients with CLL escape T-cell recognition

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Published: 15 Jun 2012
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Dr Alan G Ramsay - Barts Cancer Institute, Queen Mary University of London, UK

Dr Ramsay talks at a press conference at the 17th Congress of the European Haematology Association in Amsterdam about how malignant cells in patients with Chronic Lymphocytic Leukaemia escape T-cell recognition and attack.

Dr Alan Ramsay presented findings of a study in patients with Chronic Lymphocytic Leukaemia that will contribute to the design of immunotherapeutic strategies leading to the killing of cancer cells.

T cell activation is essential for immunity including the recognition and killing of abnormal target cells such as cancerous cells.

T cell activity is tightly regulated by signaling at the contact site (referred to as the “immune synapse”) with a target cell.

These pre-clinical findings should help contribute to the design of immunotherapeutic strategies to specifically block these inhibitory molecules in cancer and to repair T cell recognition and killing of cancer cells.

Filming supported by Amgen