Accurate diagnosis of AL amyloidosis is crucial and involves key tests like immunofixation electrophoresis and urine tests. Screening for organ damage is performed through renal function assessments and cardiac MRIs. Biopsies are essential for detecting amyloid deposits.

The ANDROMEDA study has introduced daratumumab as a leading treatment, aiming for complete haematologic remission.

Autologous stem cell transplantation may be considered for responsive patients, with future therapies potentially enhancing survival rates.