TAR-200 plus cetrelimab show encouraging outcomes for MIBC patients ineligible for standard cisplatin-based chemotherapy

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Published: 26 Mar 2025
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Dr Sarah Psutka - University of Washington, Seattle, USA

Dr Sarah Psutka speaks to ecancer about perioperative outcomes of neoadjuvant TAR-200 plus cetrelimab (CET) or CET alone in patients with muscle-invasive bladder cancer ineligible for or refusing neoadjuvant cisplatin-based chemotherapy.

The SunRISe-4 trial investigates outcomes for muscle-invasive bladder cancer by comparing a neoadjuvant strategy using a PD-1 inhibitor alone versus in combination with the TAR-200 device.

An interim analysis of 76 patients shows promising results, with a higher pathologic complete response rate for the combination therapy and limited toxicity.

The trial aims to provide alternatives for patients ineligible for standard cisplatin-based chemotherapy.