Dr Peter Borchmann speaks to ecancer about a comprehensive analysis of treatment-related morbidity and progression-free survival in the GHSG phase III HD21 trial.

The GHSG-HD21 trial for newly diagnosed adult patients with advanced-stage classical Hodgkin lymphoma (AS-cHL) compares the BrECADD regimen (Brentuximab vedotin, etoposide, cyclophosphamide, doxorubicin, dacarbazine, dexamethasone) to eBEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procar­bazine, prednisone) in a PET adapted approach.

The study found that the novel BrECADD regimen showed the highest 3-yr PFS rates reported to date in a randomised clinical trial in advanced-stage cHL. This analysis suggests that the unexpectedly high and improved efficacy of the new BrECADD regimen compared to eBEACOPP is a direct consequence of its improved tolerability and deliverability.

The results show that the optimised risk-benefit ratio of the BrECADD regimen combined with the individualised PET2-guided treatment duration sets a new benchmark for the treatment of adult patients with newly diagnosed advanced-stage cHL