Somatic and germline heterogeneity across colorectal cancer patient characteristics: Implications for early cancer detection

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Published: 24 Jul 2023
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Prof Jeffrey Weitzel - The University of Kansas Cancer Center, Kansas, USA

Prof Jeffrey Weitzel speaks to ecancer about the germline and somatic mutational landscape in patients with colorectal cancer.

The study analysed patients of various ancestries and found that the most common somatic driver mutations among all the patients were in APC (75.5%), TP53 (65.3%), TTN (48.6%), and KRAS (41.9%).

Prof Weitzel explains that this integrated analysis of germline and somatic findings across various patient characteristics is important for designing an optimum treatment for patients and for developing risk stratification strategies pertaining to early cancer detection.