Zolbetuximab + mFOLFOX6 as 1L treatment shows significantly prolonged PFS and OS in CLDN18.2+/ HER2 mG/GEJ adenocarcinoma

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Published: 25 Jan 2023
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Dr Kohei Shitara - National Cancer Center Hospital East, Kashiwa, Japan

Dr Kohei Shitara speaks to ecancer as part of ASCO GI 2023 about his study looking at zolbetuximab plus mFOLFOX6 as first-line treatment for CLDN18.2+/ HER2 metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma.

He explains that patients were randomised 1:1 to zolbetuximab plus mFOLFOX6 or placebo plus mFOLFOX6.

Dr Shitara reports that PFS was significantly improved with zolbetuximab, a statistically significant 10.6 months compared with 8.7 months.