Allogeneic haematopoietic cell transplantation in adults with Ph-like ALL

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Published: 13 Dec 2021
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Dr Ibrahim Aldoss - City of Hope, Duarte, USA

Dr Ibrahim Aldoss talks to ecancer about his talk at ASH 2021: Outcomes of allogeneic haematopoietic cell transplantation in adults with Ph-like ALL.

He begins by explaining some off the background to the study, stating that Ph-like ALL is a high risk leukaemia of B-cell ALL, that tends to be chemorefractory, with a high risk of induction failure, a high relapse rate and low overall survival.

Dr Aldoss then goes on to explain that 125 adult patients with B-cell ALL were included in the analysis, and it was found that 66 of them had Ph-like ALL. He says when characteristics of Ph-like ALL are compared with Non-Ph-like ALL it was found that Ph-like patients tend to be younger, more frequently hispanic, less likely to have high-risk cytogenetics, and more frequently used paediatric-inspired regimens.

He concludes by saying they couldn't address the benefit of transplant in patients who achieved early MRD response with chemotherapy, so believes there should be a study looking at outcomes of transplant versus non-transplant in Ph-like ALL patients who achieve an MRD negative response with moderate regimens of chemotherapy, to see if transplant is needed for these patients, or not.

ecancer's filming has been kindly supported by Amgen through the ecancer Global Foundation. ecancer is editorially independent and there is no influence over content.