Dr Ben Goldacre has given a TED talk on the pervasive issue of publication bias in medicine. When a new drug gets tested, the results of the trials should be published for the rest of the medical world - except much of the time, negative or inconclusive findings go unreported, leaving doctors and researchers in the dark.

Positive findings are twice as likely to be published as negative findings, meaning that the results of half of all trials are buried. In this impassioned talk, Dr Ben Goldacre explains why these unreported instances of negative data are especially misleading and dangerous.
http://www.ted.com/talks/ben_goldacre_what_doctors_don_t_know_about_the_drugs_they_prescribe.html

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