Supporting oncology professionals through education
The content on this site is intended for healthcare professionals only
The content on this site is intended for healthcare professionals only
A review of oncology literature compiled by Giuseppe Curigliano, Division of Medical Oncology, IEO, Milan, Italy
Pilot Study Using Molecular Profiling of Patients' Tumors to Find Potential Targets and Select Treatments for Their Refractory Cancers
Daniel D. Von Hoff et al. JCO Early release
The MP approach resulted in a longer PFS on an MP-suggested regimen than on the regimen on which the patient had just experienced progression.
External irradiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study
Bolla M et al. Lancet Oncology. 2010 October Early release
In patients with prostate cancer with high metastatic risk, immediate androgen suppression with an LHRH agonist given during and for 3 years after external irradiation improves 10-year disease-free and overall survival without increasing late cardiovascular toxicity.
10-year overall survival was 39·8% (95% CI 31·9—47·5) in patients receiving radiotherapy alone and 58·1% (49·2—66·0) in those allocated combined treatment (HR 0·60, 95% CI 0·45—0·80, p=0·0004), and 10-year prostate-cancer mortality was 30·4% (95% CI 23·2—37·5) and 10·3% (5·1—15·4), respectively (HR 0·38, 95% CI 0·24—0·60, p<0·0001).
miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma
Alexander Swarbrick et al. Nature Medicine 16 , 1134–1140 (2010)
In vivo delivery of a miR-380-5p antagonist decreases tumor size in an orthotopic mouse model of neuroblastoma. Researchers demonstrate a new mechanism of p53 regulation in cancer and stem cells and uncover a potential therapeutic target for neuroblastoma.
miR-380 overexpression cooperates with activated HRAS oncoprotein to transform primary cells, block oncogene-induced senescence and form tumors in mice.
Inhibition of endogenous miR-380-5p in embryonic stem or neuroblastoma cells results in induction of p53, and extensive apoptotic cell death.
Genome-Wide Associations and Functional Genomic Studies of Musculoskeletal Adverse Events in Women Receiving Aromatase Inhibitors
J. Ingle et al. JCO, Early release
This GWAS identified SNPs associated with MS-AEs in women treated with AIs and with a gene (TCL1A) which, in turn, was related to a cytokine (IL17). These findings provide a focus for further research to identify patients at risk for MS-AEs and to explore the mechanisms for these adverse events.
Top 10 Tips for Mentors
Philip S. Clifford and Joan M. Lakoski; Science, Oct 8, 2010
1. Assess your mentoring skills.
2. Start out right, with goal setting.
3. Begin with the right project.
4. Live your professional standards.
5. Tune up your listening skills.
6. Take an interest in your mentee.
7. Seed your mentee's growth.
8. Provide feedback that can be heard.
9. Share your network.
10. Enjoy the mentoring ride.
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