A new review paper was published in Oncotarget's Volume 14 on August 10, 2023, entitled, “Peripheral surrogates of tumour burden to guide chemotherapeutic and immunotherapeutic strategies for HPV-associated malignancies.”

With the rapid adoption of immunotherapy into clinical practice for HPV-associated malignancies, assessing tumour burden using “liquid biopsies” would further our understanding of clinical outcomes mediated by immunotherapy and allow for tailoring of treatment based on real-time tumour dynamics. 

In their new review, researchers Meghali Goswami, Jeffrey Schlom and Renee N. Donahue from the National Cancer Institute examine translational studies on peripheral surrogates of tumour burden derived from peripheral blood in HPV-associated malignancies, including levels and methylation of circulating tumour DNA (ctDNA), miRNA derived from extracellular vesicles, circulating tumour cells (CTCs), and HPV-specific antibodies and T cell responses. 

“We review their utility as prognostic and predictive biomarkers of response to chemotherapy and radiation, with a focus on how they may inform and guide immunotherapies to treat locally advanced and metastatic HPV-associated malignancies. We also highlight unanswered questions that must be addressed to translate and integrate these peripheral tumour biomarkers into the clinic.”

Source: Impact Journals LLC