In an editorial published in Oncotarget, entitled, “ERβ as a mediator of oestrogen signalling in inflammatory breast cancer", researchers Harika Nagandla and Christoforos Thomas from Houston Methodist Neal Cancer Center discuss inflammatory breast cancer (IBC).

This is a rare and aggressive form of breast cancer which accounts for 2–4% of all new breast cancer cases detected in the United States.

Even with the application of standard multi-modality treatment approach that incorporates neoadjuvant chemotherapy, radiation and surgery, the 5-year survival rate for IBC is only about 40–50%.

Breast cancer can be typically stratified into different types based on the presence of molecular drivers such oestrogen receptor (ERα), progesterone receptor (PR) or human epidermal growth factor receptor 2 (HER2), which inform the treatment choice. 

For IBC, there is a substantially higher incidence of ERα negativity compared with other forms of breast cancer that can reach up to 60%.

A specific targetable driver signalling pathway has not been identified so far. About one in three patients already have distant metastasis at the time of diagnosis, contributing to the aggressiveness and poor outcomes associated with IBC.

Despite the absence of ERα from the majority of IBC tumours, oestrogen signalling has been implicated in progression of the disease through ERα-independent pathways.

ERβ is a ligand activated transcription factor that mediates effects of oestrogen, along with ERα in different tissues during growth and development by regulating transcription of target genes.

Tumour suppressive effects of ERβ have been documented in diverse cancer types such as thyroid, kidney, prostate, glioblastoma, ovarian and breast cancer. 

Source: Impact Journals LLC