Novel imaging agent identifies biomarker for iron-targeted cancer therapies

26 Jul 2021
Novel imaging agent identifies biomarker for iron-targeted cancer therapies

A new radiotracer that detects iron in cancer cells has proven effective, opening the door for the advancement of iron-targeted therapies for cancer patients.

The radiotracer, 18F-TRX, can be used to measure iron concentration in tumours, which can help predict whether a not the cancer will respond to treatment.

This research was published in the July issue of the Journal of Nuclear Medicine.

All cancer cells have an insatiable appetite for iron, which provides them the energy they need to multiply.

As a result, tumours have higher levels of iron than normal tissues.

Recent advances in chemistry have led scientists to take advantage of this altered state, targeting the expanded cytosolic 'labile' iron pool (LIP) of the cancer cell to develop new treatments.

A clear method to measure LIP in tumours must be established to advance clinical trials for LIP-targeted therapies.

"LIP levels in patient tumours have never been quantified," noted Adam R. Renslo, PhD, professor in the department of pharmaceutical chemistry at the University of California, San Francisco.

"Iron rapidly oxidizes once its cellular environment is disrupted, so it can't be quantified reliably from tumour biopsies.

A biomarker for LIP could help determine which tumours have the highest LIP levels and might be especially vulnerable to LIP-targeted therapies."

To explore a solution for this unmet need, researchers imaged 10 tissue graft models of glioma and renal cell carcinoma with 18F-TRX PET to measure LIP.

Tumour avidity and sensitivity to the radiotracer were assessed. An animal model study was also conducted to determine effective human dosimetry.

18F-TRX showed a wide range of tumour accumulation, successfully distinguishing LIP levels among tumours and determining those that might be most likely to respond to LIP-targeted therapies.

Pretreatment 18F-TRX uptake in tumours was also found to predict sensitivity to therapy. The estimated effective dose for adults was comparable to those of other 18F-based imaging agents.

"Iron dysregulation occurs in many human disorders, including neurodegenerative and cardiovascular diseases, and inflammation," said Michael J. Evans, associate professor in residence in the department of radiology and biomedical imaging at the University of California, San Francisco.

"Applying 18F-TRX in the respective patient populations to define the extent of LIP expansion in affected tissues will be an important milestone toward understanding the therapeutic potential of LIP-targeted therapies beyond oncology."

Source: Society of Nuclear Medicine and Molecular Imaging