Oncotarget reported that in multivariate analyses, serum albumin, GNRI, pathological tumour-node-metastasis stage, and tumour differentiation were independent prognostic factors for CSS.

In pTNM stage I, multivariate analysis identified C-reactive protein and GNRI as independent prognostic factors for CSS.

In univariate analyses in pTNM stages II and III, only low GNRI and low serum albumin levels, respectively, were significantly associated with worse CSS.

In patients with low GNRI, CSS was significantly worse than in those with normal GNRI, especially in pTNM stages I and II groups, but not in stage III group.

Preoperative GNRI may sort patients into low- or high-risk groups for shorter CSS, especially in those with pTNM stage I and II ESCC.

Dr. Noriyuki Hirahara from The Shimane University Faculty of Medicine said, "Patients with advanced oesophageal cancer presenting with dysphagia often experience malnutrition as well as impairment of performance status and quality of life."

Serum albumin is a clinically relevant indicator of nutritional status, such as malnutrition and cachexia.

Recently, it has been widely accepted that the GNRI was strongly associated with mortality in elderly hospitalised patients and in patients with various cancers.

However, to the best of the authors knowledge, there have been few reports on the prognostic significance of the GNRI in patients with oesophageal squamous cell carcinoma.

In this study, they have investigated whether the GNRI is a useful predictor of long-term survivals in patients with ESCC who underwent a curative oesophagectomy.

Source: Impact Journals LLC