A joint research team led by Prof. WANG Hui and Prof. LIN Wenchu from the High Magnetic Field Laboratory of the Hefei Institutes of Physical Science developed a synthesis of metal-free multifunctional therapeutic reagents, called graphitic carbon nitride quantum dots embedded in carbon nanosheets (CNQD-CN), via a one-step hydrothermal treatment.
Metal-free multifunctional nanomaterials have broad application prospects in integrated cancer diagnosis and treatment.
The team took an organic solvent (formamide) as the carbon and nitrogen source and then developed CNQD-CN.
CNQD-CN can be utilized as a near-infrared (NIR)/pH dual-responsive drug delivery system to improve the response to chemotherapy.
It possesses both light-to-heat conversion and singlet oxygen generation capabilities under a single NIR excitation wavelength for combined photodynamic and photothermal therapy.
"The combination of graphitic carbon nitride quantum dots and two-dimensional carbon-based nanomaterials might be a potential candidate for realising imaging-guided synergistic cancer therapy due to its excellent performance, including optical properties, efficient light-to-heat conversion capability, and near-infrared (NIR)-induced singlet oxygen generation," said WANG Hui, who designed the project.
However, synthesis of related nanocomposites, including multiple reaction precursors, complex synthesis processes, potential weak interaction, produced large amounts of waste, thus limiting their scalable production and reproducibility.
This study was a further step in realising the advantages of imaging-guided synergistic cancer therapy.
We are an independent charity and are not backed by a large company or society. We raise every penny ourselves to improve the standards of cancer care through education. You can help us continue our work to address inequalities in cancer care by making a donation.
Any donation, however small, contributes directly towards the costs of creating and sharing free oncology education.
Together we can get better outcomes for patients by tackling global inequalities in access to the results of cancer research.
Thank you for your support.