Research from the University of Cincinnati (UC) reveals a potential new target to help T cells (white blood cells) infiltrate certain solid tumours.

This study, being published in the April 24 advance online edition of the journal Science Signaling, showed that by targeting a certain potassium channel--KCa3.1--the CD8 T cell migration in patient samples was restored, meaning that they could potentially be more effective in moving in on the tumour and attacking it.

CD8 cells are a type of T cell capable of killing cancer cells.

"Reduced potassium channel activity curbs T cell movement within the tumour," says Laura Conforti, PhD, professor in the Department of Internal Medicine at the UC College of Medicine, a researcher within the Cincinnati Cancer Center and UC Cancer Institute and corresponding author on the study. "T cell infiltration in solid tumours is limited by multiple factors found within the tumour's microenvironment, including adenosine, an immunosuppressive substance accumulating in high amounts in solid tumours."

Conforti and her team, led by Ameet Chimote, PhD, a research associate in the Department of Internal Medicine, analyzed the migration of CD8 T cells in a 3-D experimental model system that allows the reproduction of some features of the tumor microenvironment and found that when adenosine was present, it inhibited the movement of T cells from cancer patients more than T cells from healthy donors.

"The increased sensitivity of patient CD8 T cells to adenosine correlated with reduced KCa3.1 channel activity, but not with adenosine receptor expression or signalling," she says. "Treatment with a substance that restores the KCa3.1 channel activity corrects patient CD8 T cell migration in the presence of adenosine, suggesting that potassium channel activators may help enhance T cell infiltration of adenosine-rich solid tumours, providing another therapy option.

"This finding could lead to the development of new therapeutic agents to use in combination with approved immunomodulators for the treatment of solid tumours, as they may improve their efficacy."

Source: University of Cincinnati