Results from a large, prospective, multi-center trial at the 2018 World Congress of Endoscopic Surgery jointly hosted by the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) and the Canadian Association of General Surgeons (CAGS), show improved rates of oesophageal cancer detection with the probe-based confocal endomicroscopy platform, Cellvizio®.
The presentation was entitled, “Real-Time Diagnosis of Barrett’s Esophagus: A Prospective, Multicenter Trial Comparing Confocal Laser Endomicroscopy with Conventional Histology for the Identification of Intestinal Metaplasia in Novice Users.”
The prospective, multi-center study included 172 patients scheduled for a Barrett’s Esophagus screening or surveillance endoscopy.
Random four quadrant biopsy (Seattle protocol) performed under high-definition white light endoscopy was compared to pCLE using Cellvizio and interpreted in real time and after the procedure.
The key results were as follows:
“Monitoring gastroesophageal reflux disease (GERD) is critical because Barrett’s oesophagus is associated with increased risk of developing oesophageal cancer,” said Paul A. Severson, MD, FACS, Co-Director, Minnesota Reflux and Heartburn Center. “The current standard methodology, the Seattle protocol, is poorly followed and has a very low diagnostic yield. Probe-based Confocal Laser Endomicroscopy is considerably more sensitive, as demonstrated in this study, even when performed by novice users.”
Sacha Loiseau, Ph.D., Founder and Chief Executive Officer of Mauna Kea Technologies added, “This large multi-center study confirms that endoscopists can more than double their detection rate of patients with intestinal metaplasia and dysplasia when using Cellvizio, with a short learning curve. This demonstrates once again not only the broad applicability of the technique in clinical practice but also its significance for patient care and cancer prevention.”
Source: Mauna Kea Technologies
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