ecancermedicalscience is an open access cancer journal focused on under-resourced communities. In order to help reduce global inequalities in cancer care and treatment, we provide free access to all articles from the point of publication and we only charge authors who have specific funding to cover publication costs.

The journal considers articles on all aspects of research relating to cancer, including molecular biology, genetics, pathophysiology, epidemiology, clinical reports, controlled trials (in particular if they are independent or publicly funded trials), health systems, cancer policy and regulatory aspects of cancer care.

Akhil Kapoor

Tata Memorial Hospital, Mumbai, India

Dr Akhil Kapoor talks to ecancer about his observational study to evaluate factors predicting survival in patients of non-small cell lung cancer with poor performance status in resource-constrained settings.

He begins by explaining the reason for the study was that a lot of NSCLC patients presented with poor performance status, and all major landmark studies have excluded patients with poor performance status, meaning there is limited information available on how to treat these patients.

He then goes on to mention that out of 245 patients, 192 received oral tyrosine kinase inhibitors and supportive care, 45 received supportive care alone, while 8 patients received chemotherapy along with supportive care. Median overall survival was 3 months in patients who received oral tyrosine kinase inhibitors versus 1 month in patients who received supportive care alone.

Dr Kapoor concludes that the use of oral tyrosine kinase inhibitors on a compassionate basis led to improvement in survival in the overall cohort of the patients and that this was principally driven by EGFR-mutated patients.

Read the full article here.