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WCCS 2016 /
Metabolic regulation of melanoma cells

31st Aug - 3rd Sep 2016

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Published: 23.09.16
Views: 1798

Dr Victoria Sherwood - University of Dundee, UK

Dr Sherwood speaks with ecancertv at WCCS 2016 about metabolic regulation of melanoma cells under the control of wnt signalling pathways.

She highlights the difference between canonical and non-canonical signalling, or B-catenin dependent and independent arms of wnt signalling pathways, and how these exert metabolic control through PTEN expression.

Dr Sherwood describes PTEN melanoma cell lines as mitophagy addicted, with macroautophagy and mitophagy blocked, resulting in a changed metastatic potential.

She also comments on the work of Katharina Kober, who spoke with ecancer here.

ecancer's filming at WCCS 2016 has been kindly supported by Amgen through the ECMS Foundation. ecancer is editorially independent and there is no influence over content.

Previous conferences: highlights

Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation