My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 11 734 / https://doi.org/10.3332/ecancer.2017.734

Image Report

Brachytherapy and anterior segment imaging in iris melanoma

A 40-year-old male presented to the ophthalmology clinic with a darkly pigmented infratemporal lesion in his right eye. The corrected visual acuity in both eyes was 6/6 and both pupils were equal and reactive. Slit lamp biomicroscopy showed a well-demarcated and heavily pigmented lesion in the peripheral iris between 6 and 8 o’clock. Ultrasound biomicroscopy (UBM) revealed a solid mass deriving from the iris stroma without ciliary body involvement, helping to classify the uveal melanoma and establishing the diagnosis of iris melanoma. Fine needle aspiration (FNA) confirmed melanoma with inactivation of the BAP1 gene. The patient was treated with brachytherapy using an I-125 plaque. Follow-up UBM, three years later, demonstrated significantly reduced dimensions of the tumour. UBM has become crucial to the differentiation of uveal melanomas from benign growths, and lesions <3 mm cannot be reliably visualised by other imaging modalities or localised to the correct uveal structure. Brachytherapy represents a safe and effective treatment option even in lesions that are BAP1 positive.

Keywords: melanoma, brachytherapy, ocular, oncology, ultrasound

Loading Article Metrics ... Please wait

Related articles

Research: The mortality-incidence ratio as an indicator of five-year cancer survival in metropolitan Lima

Abstract | Full Article | PDF | Spanish Published: 18 Jan 2018 / https://doi.org/10.3332/ecancer.2018.799

Special Issue: Novel techniques for intraoperative assessment of margin involvement

Abstract | Full Article | PDF Published: 10 Jan 2018 / https://doi.org/10.3332/ecancer.2018.795

Special Issue: High-intensity focused ultrasound in the treatment of breast tumours

Abstract | Full Article | PDF Published: 10 Jan 2018 / https://doi.org/10.3332/ecancer.2018.794

Special Issue: Update on intraoperative radiotherapy: new challenges and issues

Abstract | Full Article | PDF Published: 10 Jan 2018 / https://doi.org/10.3332/ecancer.2018.793

Conference Report: Highlights from the Inaugural International Cancer Microbiome Consortium Meeting (ICMC), 5–6 September 2017, London, UK

Abstract | Full Article | PDF Published: 20 Dec 2017 / https://doi.org/10.3332/ecancer.2017.791



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence