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BYLieve study results: Alpelisib and endocrine therapy in patients with PIK3CA-mutated/HR /HER2- advanced breast cancer

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Published: 12.06.19
Views: 211

Prof Hope Rugo - University of California, San Francisco, USA

Prof Hope Rugo speaks to ecancer at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting about the results from the BYLieve study.

She describes the aim and methodology of the study, which was to assess the efficacy and toxicity of alpelisib in combination with endocrine therapy in patients who have received prior CDK4/6 inhibitors.

Prof Rugo also discusses the results from this interim analysis, which includes reasonable response rates which was in accordance with the data achieved in the SOLAR-1 study. A much lower discontinuation rate was also achieved in this study.

She believes the use of PI3-kinase inhibitors, such as alpelisib is an exciting advancement in personalising treatments for breast cancer.

 

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