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The future of PARP inhibitors in metastatic breast cancer

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Published: 12.06.19
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Prof Debu Tripathy - The University of Texas MD Anderson Cancer Center, Houston, USA

Prof Debu Tripathy speaks to ecancer at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting about the current landscape of PARP inhibitors and the future for this type of targeted therapy.

He discusses the action of these drugs along with the issue of resistance, in which some tumours are able to mutate the BRCA receptor back to the non-mutated form.

Prof Tripathy notes that further understanding is needed to understand these mechanisms of resistance along with combining other types of therapy, such as immunotherapy with PARP inhibitors.

This programme has been supported by an unrestricted educational grant from Pfizer.

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