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DORA: Using olaparib alone or with durvalumab in platinum responsive advanced triple-negative breast cancer

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Published: 12.06.19
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Dr Tira Tan - National Cancer Centre, Singapore

Dr Tira Tan speaks to ecancer at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting about the phase II DORA study.

She explains that the trial uses the PARP inhibitor olaparib alone or in combination with the PD-L1 inhibitor durvalumab to treat patients with platinum responsive advanced triple-negative breast cancer, thereby using a maintenance strategy to reduce the toxicities experienced by patients.

Dr Tan says that they are expecting some correlative work to come out of this study that will inform them on which patient populations may benefit most from this approach. She also provides her insights on the potential of PARP inhibitors in other settings.

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