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5' UTR mutations in prostate cancer

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Published: 15.04.19
Views: 707

Dr Yiting Lim, Fred Hutchinson Cancer Research Center, Seattle, USA

Dr Yiting Lim speaks to ecancer at the 2019 American Association for Cancer Research (AACR) meeting about the 5' UTR mutations that are present among the DNA of prostate cancer patients.

Dr Lim emphasises the significance of this research, as mutations in the 5' UTR are often overlooked and require more research. 

By using publically available datasets, localised patient DNA was examined for 5' UTR mutations.
The group also sequenced genomic DNA acquired from patients with metastatic castration-resistant prostate cancer. The somatic mutations identified (mostly SNPs, but some short insertions/deletions) were found to be recurrent within the whole patient cohort.

Dr Lim states that the results of this study suggest the importance of post-transcriptional regulation potential therapies should focus on mechanisms around this. She also mentions the possibility of personalising these treatments to target a patient's specific mutations.


 

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