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Gilteritinib combined with induction and consolidation chemotherapy in newly diagnosed AML patients

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Published: 06.12.18
Views: 577

Dr Keith Pratz - Johns Hopkins University, Baltimore, USA

Dr Keith Pratz speaks to ecancer at ASH 2018 about the phase 1 study into the safety, tolerability and antitumour activity of gilteritinib plus front-line intensive chemotherapy in newly diagnosed AML patients.

He explains that FLT3 is a tyrosene kinase that confers resistance to chemotherapy so adding this new FLT3 inhibitor medicine alongside the standard treatment could improve outcomes.

Dr Pratz reports that they have established a maximum dose for gilteritinib when combined with chemotherapy and also that the FLT3 mutant group of patients had an above 90% complete remission rate with the combination.

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